1/6/2023 0 Comments 3d custom girl peripheral![]() Most lesions were either entirely flat (n=14) or contained focal papillary architecture (n=7) only 4 lesions, all proximal-type, were predominantly papillary, fitting the classic description of CMPT. ![]() ![]() All bronchiolar adenomas were discrete, sharply circumscribed lesions with a median size of 0.5 cm (range: 0.2 – 2.0 cm). We provisionally designated these lesions as bronchiolar adenomas and analyzed their clinicopathologic and molecular features. The hallmark of all lesions was a continuous layer of basal cells (p40 and CK5/6-positive). The morphologic and immunohistochemical features ranged from those resembling proximal bronchioles (proximal-type: moderate to abundant mucinous and ciliated cells negative or weak TTF1 in luminal cells n=8) to those resembling respiratory bronchioles (distal-type: scant or absent mucinous and ciliated cells positive TTF1 in luminal cells n=17). These lesions shared some histologic features with the recently described entity of ciliated muconodular papillary tumor (CMPT) however, the majority did not fit all diagnostic criteria in that they exhibited only focal or absent papillary architecture, and they had variable number of ciliated and mucinous cells, with some lesions entirely lacking one or both of these components. We have identified 25 lesions involving alveolar lung parenchyma characterized by nodular proliferation of bland bilayered bronchiolar-type epithelium containing a continuous layer of basal cells.
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